DIM Detox

DIM Detox is Pure Encapsulations' most comprehensive hepatic detoxification and hormone metabolism support formula—a ten-ingredient combination that addresses oestrogen metabolism, phase II liver detoxification, antioxidant protection, and support for the glucuronidation pathway in a single, clinically formulated product. Unlike simpler DIM-only supplements, this formula is designed around the understanding that healthy oestrogen processing requires not just the initial metabolic steps but the full downstream detoxification cascade — from phase I oestrogen hydroxylation through phase II conjugation and elimination.

The formula operates across four complementary functional mechanisms:

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1. Oestrogen Metabolism Support — BioResponse DIM® and Broccoli Sprout Concentrate

BioResponse DIM® (Diindolylmethane Complex) — 100mg (providing 25mg DIM) Diindolylmethane (DIM) is a stable metabolite of indole-3-carbinol (I3C), naturally formed when cruciferous vegetables are chewed and digested. DIM's principal mechanism is the promotion of favourable oestrogen metabolism — specifically, it supports the 2-hydroxylation pathway of oestrogen metabolism, favouring the production of 2-hydroxyoestrone (2-OHE1) over the more biologically active and potentially proliferative 16α-hydroxyoestrone (16α-OHE1) and 4-hydroxyoestrone (4-OHE1). This shift in the 2:16 oestrogen metabolite ratio is considered a meaningful marker of healthy oestrogen metabolism in both women and men.

Plain DIM has poor water solubility and bioavailability. BioResponse DIM® is a patented delivery system (US Patent 6,086,915) that complexes DIM with starch, phosphatidylcholine, vitamin E succinate, and silica — creating a microencapsulated complex that significantly enhances DIM's absorption and oral bioavailability compared to unformulated DIM powder. The 100mg complex provides 25mg of actual DIM per serving.

Broccoli Sprout Concentrate (Brassica oleracea italica, whole plant, standardised to minimum of 400 mcg sulforaphane) — 100mg Sulforaphane, the principal bioactive derived from glucoraphanin in broccoli sprouts, is the most potent known inducer of the Nrf2 (nuclear factor erythroid 2-related factor 2) transcription pathway — the master regulator of the body's endogenous antioxidant and phase II detoxification enzyme systems. Sulforaphane induces the expression of detoxification enzymes, including glutathione S-transferase (GST), NAD(P)H quinone oxidoreductase 1 (NQO1), and UDP-glucuronosyltransferases (UGTs) — enzymes directly involved in the conjugation and elimination of oestrogen metabolites, carcinogens, and environmental toxicants. The broccoli sprout concentrate also serves as a natural source of indole-3-carbinol, the DIM precursor.

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2. Glucuronidation Pathway Support — Calcium D-Glucarate

Calcium D-Glucarate™ (patented, Applied Food Sciences) — 100mg As covered in the standalone Calcium D-Glucarate listing, this ingredient supports healthy hormone elimination through the glucuronidation detoxification pathway by inhibiting beta-glucuronidase — the enzyme that can deconjugate and reactivate oestrogen metabolites before they are excreted, allowing them to re-enter circulation. By supporting beta-glucuronidase regulation, calcium D-glucarate helps ensure that conjugated oestrogen metabolites complete their elimination cycle rather than being reabsorbed. This mechanism is directly complementary to DIM's role in promoting favourable oestrogen hydroxylation — DIM shifts which oestrogen metabolites are produced, while calcium D-glucarate supports their efficient elimination.

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3. Phase II Liver Detoxification Support — Milk Thistle, Alpha Lipoic Acid, NAC, and Amino Acids

Milk Thistle Extract (Silybum marianum, seed, standardised to 80% silymarin) — 150mg Silymarin — the flavonolignan complex from milk thistle seed — is one of the most extensively researched hepatoprotective botanicals. It supports phase II detoxification enzyme activity, provides antioxidant protection to hepatocytes, promotes hepatic glutathione levels, and has demonstrated liver membrane-stabilising properties. The 80% silymarin standardisation ensures consistent delivery of the active fractions responsible for these effects.

Alpha Lipoic Acid (ALA, thioctic acid) — 200mg ALA is a universal antioxidant — unique in its ability to quench both fat-soluble and water-soluble free radicals — and a critical cofactor for mitochondrial energy metabolism. In the context of liver detoxification, ALA supports phase II enzyme activity, regenerates endogenous antioxidants including glutathione and vitamins C and E, and provides direct antioxidant protection during the oxidative burden associated with phase I detoxification reactions.

N-Acetyl-L-Cysteine (NAC, free-form) — 200mg NAC is the immediate precursor to L-cysteine, the rate-limiting substrate for glutathione synthesis. As the body's primary endogenous antioxidant and a critical phase II conjugation agent, glutathione is essential for the detoxification of reactive oestrogen metabolites (particularly 4-catechol oestrogens), environmental xenobiotics, and oxidative stress byproducts of normal metabolism. NAC supplementation reliably and dose-dependently raises hepatic and systemic glutathione levels.

L-Methionine (free-form) — 200mg L-methionine is an essential amino acid that supports glutathione production (through transsulfuration), contributes to methylation reactions via the SAM (S-adenosylmethionine) cycle, and supports healthy hepatic fat metabolism and bile flow — all directly relevant to phase II detoxification efficiency.

Glycine (free-form) — 100mg Glycine is a phase II conjugation substrate used directly in the glycine conjugation pathway for the elimination of bile acids, xenobiotics, and certain organic acids. It is also a structural component of glutathione and a hepatoprotective amino acid.

Taurine (free-form) — 100mg Taurine is abundant in liver cells where it functions as an important component of bile acid conjugates (taurocholic acid), facilitating the emulsification and absorption of fat-soluble vitamins and supporting the elimination of bile acid-bound toxins. Taurine also acts as a cellular osmoregulator and antioxidant, protecting hepatocytes under oxidative stress.

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4. Lignan Support — HMRlignan™

HMRlignan™ (Norway spruce knot wood, 7-hydroxymatairesinol) — 10mg HMRlignan™ is a patented lignan extract from Norway spruce (Linnea Inc.) providing 7-hydroxymatairesinol (HMR), a plant lignan converted by intestinal bacteria to the mammalian lignan enterolactone. Enterolactone has demonstrated weak oestrogenic and anti-oestrogenic properties depending on cellular context, and research indicates that higher dietary lignan intake and healthy serum enterolactone levels are associated with supportive outcomes for cellular, cardiovascular, bone, and cognitive health. The inclusion of HMRlignan™ at a clinically meaningful 10mg dose adds a further dimension to the formula's hormone metabolism and cellular health profile.

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What Sets This Product Apart

DIM Detox addresses oestrogen metabolism and hepatic detoxification through four mechanistically distinct but highly complementary pathways in a single, two-capsule daily dose. This is considerably more clinically sophisticated than standalone DIM supplements, DIM + I3C combinations, or even DIM + calcium D-glucarate products. The inclusion of sulforaphane (Nrf2/phase II induction), silymarin (hepatoprotection), ALA + NAC (glutathione support and antioxidant protection), phase II amino acid conjugation substrates (glycine, taurine, methionine), and HMRlignan™ alongside the patented BioResponse DIM® and Calcium D-Glucarate™ creates a formula that supports the complete oestrogen processing and elimination cycle — from initial hydroxylation through conjugation, glucuronidation, and biliary/urinary elimination.

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Supplement Facts

Serving Size: 2 capsules Servings Per Container: 30

Other Ingredients: Vegetarian capsule (cellulose, water), hypoallergenic plant fibre (cellulose), ascorbyl palmitate.

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Directions for Use

Adults: Take 2 capsules daily with meals, or as directed by your healthcare practitioner.

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Allergen Information

Free from gluten, wheat, dairy, soy, eggs, tree nuts, peanuts, GMOs, artificial colours, flavours, sweeteners, coatings, shellacs, magnesium stearate, and unnecessary binders or preservatives. Hypoallergenic. Vegan and vegetarian suitable.

Note: The BioResponse DIM® complex contains phosphatidylcholine, which is derived from soy lecithin in some formulations — however Pure Encapsulations lists this product as soy-free; confirm directly with Pure Encapsulations if you have a soy-sensitive patient.

Cautions: Not recommended during pregnancy or lactation without professional supervision. If you are taking medications — particularly hormonal medications, anticoagulants, or hepatically metabolised drugs — consult your healthcare practitioner before use. Calcium D-glucarate may theoretically increase the elimination rate of certain medications metabolised via glucuronidation. Keep out of reach of children.

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Practitioner Note

Recommended by Stephen Roigard, Naturopath & Clinical Nutritionist. DIM Detox is the most clinically complete oestrogen metabolism and hepatic detoxification support product in the Pure Encapsulations range, and one of the most comprehensively formulated products of its type available at the practitioner level. It is well indicated in presentations of oestrogen dominance, PMS with fluid retention or breast tenderness, perimenopausal hormonal dysregulation, PCOS with oestrogenic features, endometriosis, or any clinical context where the 2:16 oestrogen metabolite ratio is suboptimal or where hepatic phase II conjugation capacity requires support. The combination of DIM (2-hydroxylation promotion) + calcium D-glucarate (glucuronidation support) + NAC/ALA/glutathione support represents a complete oestrogen clearance pathway protocol in two capsules. The sulforaphane-standardised broccoli sprout concentrate adds meaningful Nrf2 induction — relevant both for oestrogen metabolism and for broader hepatic and cellular protection. The soy-derived phosphatidylcholine in BioResponse DIM® is worth noting in highly soy-sensitive patients, though the manufacturer lists the product as soy-free.

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This product is a dietary supplement intended to support general health and well-being. It is not intended to diagnose, treat, cure, or prevent any medical condition. This product has not been evaluated by Medsafe. If symptoms persist or worsen, consult a qualified healthcare practitioner.