Women's Nutrients

Women's Nutrients 40+ is a comprehensive multivitamin, mineral, and trace element complex specifically formulated to address the nutritional priorities of women over 40. Beyond a conventional micronutrient base, the formula integrates five targeted proprietary blends — BreastHealth Plus, MacularSynergy Complex, Cardio Polyphenol Complex, StressCalm Blend, and Urinary Health Support — alongside several clinically validated trademarked ingredients.

Micronutrient Foundation The formula provides activated and bioavailable forms of key vitamins and minerals throughout. Folate is supplied as Metafolin® L-5-MTHF — the naturally occurring, physiologically active form of folate that is universally metabolised regardless of MTHFR polymorphism status, in contrast to synthetic folic acid, which requires enzymatic conversion that a significant proportion of the population cannot perform efficiently. Vitamin B12 is provided as methylcobalamin, the neurologically active form. B2 and B6 are delivered in part as their coenzyme forms (riboflavin 5'-phosphate and pyridoxal 5'-phosphate respectively), bypassing the hepatic activation steps required by standard forms. All minerals are provided in superior chelated forms — calcium, magnesium, zinc, and manganese as citrates; selenium as selenomethionine; chromium as chromium polynicotinate — for enhanced gastrointestinal absorption and tolerability.

Calcium is supplied as calcium citrate at 200 mg per serving (400 mg at full daily dose of 6 capsules) — the highest elemental calcium dose across the entire Pure Encapsulations multivitamin range — together with vitamin D3 (as cholecalciferol) and vitamin K1 to support healthy bone mineralisation.

Antioxidant Complex A broad-spectrum antioxidant profile is provided by naturally derived vitamin C, vitamin E (as d-alpha tocopherol succinate), beta carotene, a proprietary mixed carotenoid blend (lutein, lycopene, zeaxanthin), and alpha lipoic acid. Biotin at 1,000 mcg per serving supports healthy hair, skin, and nail integrity.

BreastHealth Plus This targeted blend combines HMRlignan™ — a standardised 7-hydroxymatairesinol (7-HMR) lignan derived from Norway spruce (Picea abies) knot wood — with green tea (Camellia sinensis) extract standardised to 65% total catechins and 23% EGCG, Curcumin C3 Complex® (turmeric (Curcuma longa) root extract standardised to 95% curcuminoids), and calcium-D-glucarate. HMRlignan™ is a clinically studied enterolactone precursor. In a randomised, double-blind trial, HMRlignan™ was shown to help maintain comfort and wellbeing during the menopause transition. Green tea catechins and curcuminoids contribute broad antioxidant support for breast tissue health.

MacularSynergy Complex Provides FloraGLO® lutein (3 mg) and OPTISHARP® zeaxanthin (500 mcg) — both trademarked, clinically referenced forms — alongside vitamin C, vitamin E, zinc, and carotenoids, to support the integrity of the macula and retina. FloraGLO® is the most extensively researched lutein ingredient globally, with multiple randomised controlled trials supporting its effect on macular pigment optical density.

Cardio Polyphenol Complex A concentrated polyphenol blend combining red wine (Vitis vinifera) concentrate standardised to 25% total polyphenols, grape seed (Vitis vinifera) extract standardised to 92% polyphenols, and pomegranate (Punica granatum) extract standardised to 40% punicosides. This combination provides diverse polyphenolic cofactors to help maintain healthy vascular function and endothelial integrity.

StressCalm Blend Rhodiola (Rhodiola rosea) root extract standardised to 3% total rosavins and 1% salidroside is included at 50 mg per serving for its adaptogenic properties. Lemon balm (Melissa officinalis) leaf extract, standardised to 5% rosmarinic acid (25 mg per serving), provides complementary calming support. Both ingredients have been evaluated in clinical trials for their role in helping to moderate the physiological response to occasional stress.

Urinary Health Support Cranberry (Vaccinium macrocarpon) concentrate (50 mg per serving) is combined with vitamin C to help maintain healthy urinary tract ecology.

---

Why Women's Nutrients 40+?

This formulation stands apart from standard women's multivitamins on several grounds that matter in a practitioner context:

• Activated B vitamins throughout. Metafolin® L-5-MTHF rather than folic acid, methylcobalamin rather than cyanocobalamin, and coenzyme forms of B2 and B6 — this matters clinically, particularly for women with MTHFR variants or compromised hepatic conversion capacity, which is not uncommon in the over-40 demographic.
• Multiple proprietary trademarked ingredients with their own evidence bases. HMRlignan™, FloraGLO®, OPTISHARP®, and Curcumin C3 Complex® are each supported by independent clinical research, not commodity extracts.
• Targeted blends addressing the specific physiological shifts of the post-40 transition — bone density, macular health, breast tissue integrity, vascular function, HPA axis support, and urinary health — in a single formulation.
• Hypoallergenic manufacturing standard. Free from wheat, gluten, dairy, soy, eggs, tree nuts, peanuts, sesame, artificial colours, flavours, sweeteners, magnesium stearate, shellacs, GMOs, and unnecessary fillers or preservatives.
• Vegetarian formulation using only cellulose capsule shells with no animal-derived excipients.

---

Supplement Facts

Serving Size: 3 Capsules Servings Per Container: 60 (180-capsule bottle)

Other Ingredients: Vegetarian capsule (cellulose, water), ascorbyl palmitate, cranberry fibre, cranberry seed oil, guar gum, sunflower lecithin.

---

Directions for Use

Take 3 capsules once or twice daily with meals, or as directed by your healthcare practitioner.

---

Allergen Information

Free from: gluten, wheat, dairy, soy, eggs, tree nuts, peanuts, sesame, artificial colours, flavours, sweeteners, magnesium stearate, shellacs, GMOs, and unnecessary fillers or preservatives. Suitable for vegetarians. Contains no iron.

---

Cautions & Contraindications

• Vitamin K1 may be contraindicated with anticoagulant medications, including warfarin (Coumadin). Consult your healthcare practitioner before use.
• Grape seed extract, cranberry, curcumin, and green tea extract may interact with blood-thinning medications. Consult your healthcare practitioner before use.
• Calcium-D-glucarate and curcumin may theoretically influence hepatic drug metabolism via glucuronidation and CYP450 pathways respectively. Consult your healthcare practitioner if taking any medications.
• Turmeric (Curcuma longa) is not recommended for individuals with bile duct obstruction.
• Turmeric, green tea, and lemon balm have occasionally been associated with gastrointestinal discomfort, including nausea, bloating, and dyspepsia; take with food.
• If you have liver disease or a liver condition, consult your healthcare practitioner before use.
• Not recommended during pregnancy or lactation without professional supervision.
• Keep out of reach of children.
• Store in a cool, dry place.

---

Practitioner Notes — Stephen Roigard

This is one of the most thoughtfully composed women's multivitamin formulas available in the practitioner channel, and its clinical differentiation from retail-grade products is significant. Key points for patient discussion:

MTHFR and activated B vitamins: The use of Metafolin® L-5-MTHF (rather than folic acid) and methylcobalamin (rather than cyanocobalamin) is clinically meaningful in the over-40 female demographic, where MTHFR heterozygosity is common and hepatic conversion capacity may be reduced. For patients who have had prior folate-sensitive pregnancy complications, a history of elevated homocysteine, or any identified methylation concerns, this is a genuine clinical advantage over most multivitamins.

HMRlignan™ and the menopause transition: The 5 mg dose of HMRlignan™ (7-hydroxymatairesinol) aligns with the doses used in clinical trials. HMR is a secoisolariciresinol-type lignan that is converted by intestinal microbiota to enterolactone — a major circulating phytoestrogen. At 6 capsules daily (full dose), the patient receives 10 mg HMRlignan™ per day, which is well within the studied ranges. This is relevant for patients navigating perimenopause or menopause who prefer a non-hormonal nutritional approach.

Vitamin D3 at 500 IU (full dose 1,000 IU): This sits at the lower end of therapeutic dosing for women over 40 and is appropriate as a maintenance/foundational dose. For patients with confirmed vitamin D insufficiency or deficiency, a standalone vitamin D3 supplement will likely be required in addition to this product.

Calcium at 200 mg per serving (400 mg at full dose): This contributes meaningfully to dietary calcium intake but should not be considered a standalone therapeutic calcium dose for established bone loss. This formula is best positioned as a foundational nutritional support product, with higher-dose calcium citrate supplemented separately where clinically indicated.

No iron: The formulation is deliberately iron-free, which is appropriate for women over 40 where iron accumulation risk increases with declining menstrual losses. This is an important point to communicate to patients moving from an iron-containing premenopausal multivitamin.