Poly-Prebiotic

Poly-Prebiotic Powder is a research-informed, multi-ingredient prebiotic formula combining two clinically studied prebiotic fibres with a polyphenol-rich botanical blend — designed to support microbiome diversity, selectively nourish keystone gut bacteria, and promote gastrointestinal barrier integrity. Unlike single-ingredient prebiotic supplements, the formula targets multiple distinct microbial populations simultaneously, reflecting the emerging scientific understanding that microbiome resilience is built on diversity rather than the abundance of any single strain.

The formula's prebiotic backbone consists of two distinct, proprietary fibre technologies:

PreticX™ Xylooligosaccharide (XOS) — 1.4g per serving PreticX™ is a patented, clinically researched xylooligosaccharide derived from non-GMO corncob, manufactured by AIDP Inc. XOS is a short-chain prebiotic fibre with high selectivity for Bifidobacterium species — one of the most clinically important genera of gut bacteria, associated with healthy immune modulation, gut barrier integrity, and reduced intestinal permeability. Multiple clinical studies have demonstrated that XOS supplementation at doses consistent with this formula increases Bifidobacterium counts significantly within as little as two to four weeks, and with notably lower reported gastrointestinal side effects (bloating, flatulence) than longer-chain prebiotic fibres such as inulin or fructooligosaccharides (FOS) at equivalent doses. PreticX™ is also demonstrably effective at lower doses than many competing prebiotic fibres, making it a more practical option for sensitive individuals.

BioEcolians® α-Glucooligosaccharide (α-GOS) — 1g per serving BioEcolians® is a patented α-glucooligosaccharide (α-GOS) developed by Solabia Group, distinct in structure from the more widely encountered β-galactooligosaccharides (β-GOS) found in many prebiotic products. Preclinical and early clinical research on α-GOS suggests selective prebiotic activity, particularly on Akkermansia muciniphila — a mucin-degrading bacterium that resides in the intestinal mucus layer and is increasingly recognised as a keystone species for gut barrier health, metabolic function, and immune regulation. Reduced Akkermansia muciniphila abundance has been associated with compromised gut barrier integrity in multiple research contexts, and supporting its growth through selective prebiotic feeding represents a clinically meaningful target for gut health protocols.

Polyphenol Complex — Cranberry, Blueberry, and Pomegranate Polyphenols — plant-derived compounds including proanthocyanidins, anthocyanins, and ellagitannins — exert prebiotic-like effects in the gut through their selective influence on microbial populations, despite not being classified as traditional dietary fibre. Unabsorbed polyphenols reaching the large intestine are metabolised by gut bacteria, generating bioactive metabolites (including urolithins from ellagitannins) while simultaneously selectively favouring the growth of beneficial bacterial populations. The three polyphenol sources in this formula are:

• Cranberry Extract (Vaccinium macrocarpon, 1.2g, standardised to 12mg proanthocyanidins/PACs) — cranberry PACs have well-documented anti-adhesion properties against pathogenic bacteria, and emerging research suggests selective prebiotic effects on Bifidobacterium and Lactobacillus populations
• Blueberry Extract (Vaccinium angustifolium, 100mg, standardised to 4% polyphenols) — anthocyanin-rich extract with established antioxidant activity and emerging evidence for selective microbiome-modulating properties
• Pomegranate Juice Powder (Punica granatum, 500mg) — providing ellagitannins (including punicalagin) that are converted by gut bacteria to urolithins, which in turn exert anti-inflammatory activity on colonocytes and demonstrate selective prebiotic effects on Akkermansia muciniphila and other beneficial species

The powder is lightly flavoured with citric acid, malic acid, and stevia leaf extract — shelf-stable and easily mixed into water, juice, smoothies, or food, with no refrigeration required.

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What Sets This Product Apart

The majority of prebiotic supplements on the market provide a single prebiotic fibre — most commonly inulin or FOS — at doses that frequently cause significant gastrointestinal side effects, and with no consideration for polyphenol-mediated microbiome modulation. Poly-Prebiotic Powder combines two distinct, proprietary prebiotic fibres with complementary bacterial selectivity (PreticX™ XOS for Bifidobacterium, BioEcolians® α-GOS for Akkermansia muciniphila) alongside a polyphenol blend that amplifies and extends the prebiotic effect through a mechanistically distinct pathway. This multi-targeted approach is more consistent with the complexity of a healthy microbiome than single-strain or single-fibre products, and the use of patented, clinically characterised ingredients provides confidence in the active fractions delivered per serving.

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Supplement Facts

Serving Size: 1 scoop (approximately 4.6g) Servings Per Container: Approximately 30

Other Ingredients: Citric acid, malic acid, stevia leaf extract.

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Directions for Use

Adults: Take 1 serving (1 scoop) once or twice daily, mixed into a beverage or food. May be added to water, juice, smoothies, or yoghurt. No refrigeration required. Or as directed by your healthcare practitioner.

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Allergen Information

Free from gluten, wheat, dairy, soy, eggs, tree nuts, peanuts, GMOs, artificial colours, artificial flavours, artificial sweeteners, coatings, shellacs, and unnecessary binders or preservatives. Hypoallergenic. Vegan and vegetarian suitable. Sweetened with stevia leaf extract only.

Cautions: If you are pregnant, lactating, have a medical condition, or are taking medications, consult your healthcare practitioner before use. As with all prebiotic fibres, some individuals may experience mild and transient gastrointestinal adjustment symptoms (such as increased flatulence or bloating) when first introducing prebiotic supplementation — beginning with a half-serve and gradually increasing over one to two weeks can minimise this. Keep out of reach of children.

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Practitioner Note

Recommended by Stephen Roigard, Naturopath & Clinical Nutritionist. Poly-Prebiotic Powder is well-suited to gut microbiome support protocols where increasing microbiome diversity, supporting Bifidobacterium populations, or targeting Akkermansia muciniphila is a clinical priority. The dual-fibre approach (XOS + α-GOS) with complementary selectivity is a meaningful clinical upgrade over single-fibre prebiotic products, and the lower GI side-effect profile of XOS relative to inulin/FOS makes this more appropriate for sensitive patients and those early in gut restoration protocols. The polyphenol component adds an additional layer of microbiome-modulating activity that aligns well with the growing evidence base for dietary polyphenols as functional prebiotic agents. The formula pairs logically with Pure Encapsulations' probiotic products, as well as with Pendulum Metabolic Daily, for patients in whom Akkermansia muciniphila support is a specific clinical target. As with all prebiotic products, dose-titration at introduction is recommended for patients with prior dysbiosis or gastrointestinal sensitivity.

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This product is a dietary supplement intended to support general health and well-being. It is not intended to diagnose, treat, cure, or prevent any medical condition. This product has not been evaluated by Medsafe. If symptoms persist or worsen, consult a qualified healthcare practitioner.